Let's consider Orexin/hypocretin receptor signalling and how we may exploit this system for brain cancer management. As we can see in the diagrams below, orexin neutrons regulate various activities such as wakefulness, feeding, reward and thermogenesis. A ketogenic diet, normalisation of sleep/wake cycles, fasting, stimulation of thermogenic pathways and giving the brain fuels it thrives on could act as key strategies we can adopt to take advantage of the fact that orexin appears to have potential as a novel, highly-specific treatment for various localised and metastatic cancers. This is not quite as simple as it may sound as you can always have too much of a 'good' stressor or thing before it becomes 'bad'- eustress vs distress. We know of course that fat is a very efficient source of energy for the brain and ketone bodies are neuroprotective, the body energy level influences orexin neuronal activity to coordinate arousal and energy homeostasis. Management of chron...
This is finally in the news thanks to the Surviving Terminal Cancer film! http://www.telegraph.co.uk/lifestyle/wellbeing/healthadvice/11424747/The-professor-who-cured-his-cancer-with-a-cocktail-of-everyday-pills-and-20-years-on-remains-disease-free.html Please sign this petition so we can save more lives like this. We want to ensure innovative therapies get to brain tumour patients as quickly as possible. http://epetitions.direct.gov.uk/petitions/74463?dm_t=0,0,0,0,0
Have you noticed the similarities between skin cancer and brain cancer? The darker a person's skin, the less likely they are to get both cancers. You are unlikely to see a dark skinned black person with a brain tumour. Both cancers have temozolomide as treatment. I have seen cases where a certain drug that is used primarily for skin cancer has had a beneficial response for brain cancer. The same is true for immunotherapy. Vitamin D3 has profound anticonvulsant properties when you have the correct amount for your body, if you are deficient you do worse. It is a well known fact that many Asians and North Africans are deficient in vitamin D so the earlier fact about skin pigmentation is largely ignored for brain cancer when you look at the stats. Just a few thoughts I've had that I wanted to share. Some 'controversial' opinions I have. Here is some possible evidence for this: 'The risk for primary brain tumors in Caucasians is higher, as much as two-fold with gliomas,...
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