An explorative essay: Can magnesium chloride raise seizure threshold?
Exploiting ionic changes in the epileptic brain to increase seizure threshold with oral supplementation of magnesium chloride Epilepsy is a serious neurological disorder marked by sudden recurrent episodes of sensory disturbance, loss of consciousness, or convulsions, associated with abnormal electrical activity in the brain. Seizures are associated with neuronal ionic changes (Schwartzkroin, 1998) that can be managed with increased efficacy through magnesium chloride supplementation. Magnesium supplementation should be part of an essential component of a management strategy for any type of epilepsy to raise seizure threshold and maintain trace element homeostasis. The form of magnesium that has been used most clinically and has the longest therapeutic use to treat epilepsy in the literature is magnesium sulphate, however this is not practical or convenient for patients with epilepsy. While there needs to be more research into other forms of magnesium to manage epilepsy, there remains ...
