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Orexin/hypocretic receptor signalling and cancer.

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Let's consider Orexin/hypocretin receptor signalling and how we may exploit this system for brain cancer management. As we can see in the diagrams below, orexin neutrons regulate various activities such as wakefulness, feeding, reward and thermogenesis. A ketogenic diet, normalisation of sleep/wake cycles, fasting, stimulation of thermogenic pathways and giving the brain fuels it thrives on could act as key strategies we can adopt to take advantage of the fact that orexin appears to have potential as a novel, highly-specific treatment for various localised and metastatic cancers. This is not quite as simple as it may sound as you can always have too much of a 'good' stressor or thing before it becomes 'bad'- eustress vs distress. We know of course that fat is a very efficient source of energy for the brain and ketone bodies are neuroprotective, the body energy level influences orexin neuronal activity to coordinate arousal and energy homeostasis. Management of chron...
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Surviving Terminal Cancer- finally in the news!

This is finally in the news thanks to the Surviving Terminal Cancer film!  http://www.telegraph.co.uk/lifestyle/wellbeing/healthadvice/11424747/The-professor-who-cured-his-cancer-with-a-cocktail-of-everyday-pills-and-20-years-on-remains-disease-free.html Please sign this petition so we can save more lives like this.  We want to ensure innovative therapies get to brain tumour patients as quickly as possible.  http://epetitions.direct.gov.uk/petitions/74463?dm_t=0,0,0,0,0
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Exercise and brain cancer

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Exercise and brain cancer is a very complex subject that I would like to revisit later. I am able to function fairly well now but it was a very long journey with many uncertainties. Walking up and down the hall at home used to be strenuous exercise for me not long ago and stairs was a nightmare. I still can't believe what I can do now. I continue to be wary of tumour recurrence after being informed by my oncologist it would probably be 'sudden, unexpected, and will likely leave me with right sided paralysis because of where the tumour was located' but that is why I'm trying all I can to keep it away! I seem to be doing alright so far, let's hope that continues.  Ketosis has become an exciting journey and I love how it alleviates and manages a lot of my symptoms when I get it right but exercise can be a challenge (trying to maintain 'therapeutic ketosis for cancer management). This morning I decided to do a little experiment (my meds often send me into a deep sle...
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