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I am inclined to conclude that the studies presented here in relation to fasting and autophagy provide sufficient evidence to support a key aspect of my metabolic strategy to manage brain cancer.... and no, its not just because I am biased. ;-) I have been experimenting with personalised fasting protocols lately, allowing for what I feel could be a theoretically viable symbiotic relationship of periodic, habitual therapeutic fasting + complimentary dose specific supplementation of fish oils + salt preparations + magnesium chloride supplementation as a specific, targeted, individualistic approach. I base this approach on my exhaustive research undertaken over the years following my diagnosis, scrutinising decades of evidence based, peer reviewed research to falsify or validate my hypotheses. I will attempt to explain why and how I believe implementation of such an approach could yield positive results for my n=1 experiment: Numerous individuals have queried my dietary protocol, howe...

Following on from my last post, I have been questioning myself more about optimal dosages for supplementation of curcumin, particularly in light of such studies whereby 'high' amounts of the compound are tolerated with minimal to zero toxicity reported. One particular study caught my eye. 'A dose escalation study was conducted to determine the maximum tolerated dose and safety of a single dose of standardized powder extract, uniformly milled curcumin ( C 3   Complex �, Sabinsa Corporation). Healthy volunteers were administered escalating doses from 500 to 12,000 mg.'  http://bmccomplementalternmed.biomedcentral.com/articles/10.1186/1472-6882-6-10 12,000 mg is a lot considering I take 1,500 mg per day which I deem to be the optimal therapeutic dose for me as an individual. There may be situations by which higher doses may be more beneficial though I believe the dosages I maintain at the moment should be adequate for my current aims.  The results of the study revealed som...

I take curcumin regularly. This is a nice visual representation of how it potentially acts as an anti-cancer agent providing all conditions requiring therapeutic efficacy are met. http://hrjournal.net/article/view/1325 Bioavailability is key here to make the most of the therapeutic benefits of curcumin. If you take it as a supplement make sure it is paired with piperine and is taken in therapeutic doses. We need more in vivo studies in brain tumour patients to elucidate what would act as an optimal dose, crossing the blood brain barrier so I will continue to research this medicinal compound.  'Major reasons contributing to the low plasma and tissue levels of curcumin appear to be due to poor absorption, rapid metabolism, and rapid systemic elimination. To improve the bioavailability of curcumin, numerous approaches have been undertaken. These approaches involve, first, the use of adjuvant like piperine that interferes with glucuronidation; second, the use of liposomal curcumin; thi...

I've been saying for a while now that these ketogenic diet proposals for cancer management have been deeply flawed- the inclusion of dairy and the lack of consideration for the role particular amino acids play in proliferation of these defective cells.  http://www.medicaldaily.com/brain-cancer-amino-acids-tryptophan-380397